Just a thought. If you get the exception error it can mean that you've saved the servers file in the wrong place. Remember that the servers file is the one you need to edit to include your username and password and it is used by the application to automatically upload your results to the web.
It looks like the exception message could mean that you've saved the servers file in the wrong place and your the application can't locate it. Rob, is the Conf directory containing the Servers file saved in the path specified within your exception message (i.e. Users\Home\Desktop)? If it isn't, you may need to cut and paste it to this directory.